CBD or cannabidiol is deprived of psychoactive properties, but it will help with various diseases
Recently, the main topics medical marijuana has been surfacing more and more regularly in foreign media, scientists are trying their finest to have permissions and funding for research of this type, believing in its promise, and in lots of countries of the world, decriminalization and legalization are underway.
Most hype now causes a substance such as for instance CBD or cannabidiol contained in the hemp plant. Today it can be found anywhere – from food to decorative cosmetics and quite legally purchased cbd gummies for pain uk in online stores in the shape of oil. And all because CBD does not need psychoactive properties, unlike tetrahydrocannabinol (THC), but it has healing properties.
Since CBD is a dynamic part of marijuana itself, you can get profit from it by smoking a joint in the old fashioned way. The most important thing is always to make sure that a quality with a predominance of this kind of substance, rather than THC, is clogged in your joint in the event that you would like to relax and relieve anxiety or pain, and not, as usual, get stuck in the couch, unsuccessfully trying to regulate paranoia.
Let’s try to figure out how this magical cannabidiol works, on the basis of the latest data from the world of science and the ability of consumers using CBD as a medication, and not for fun.
The difference between the consequences of CBD and THC
Since cannabidiol is not really a psychoactive substance, you can’t get high as a result, but it’s easy to increase your productivity, relieve anxiety and relieve pain. When using CBD, thoughts are not confused, memory does not deteriorate, and as a result of muscle relaxation, you don’t turn into a vegetable, as is often the case with smoking cannabis varieties with a predominance of THC.
If the ratio of those substances is approximately the same, then you will see a slight euphoric and the above-mentioned beneficial effects at the same time. At the same time frame, such negative consequences as paranoia, dry mouth, becoming dry and redness of the eyes, hunger and gluttony, drowsiness, and short-term memory problems, which are generally brought on by THC, don’t occur. Such varieties are most often used as a painkiller.
Although CBD works well alone, some experts still insist that in conjunction with other active components of marijuana, it brings more benefits:
“To attain a better therapeutic effect, you need a mix of cannabidiol, THC, and terpenoid phytochemicals,” says psychiatrist doctor at Harvard Medical School Lester Greenspoon.
However, how exactly this effect is achieved, scientists can not yet say with accuracy. This knowledge gap is caused, first of all, by too little research data, considering that the field of studying the healing properties of hemp is still in its infancy. Nevertheless the gradual legalization of medical marijuana implies that scientists will quickly do have more freedom due to their experiments. So hold the fists, hope and believe.
What diseases cannabidiol helps to manage with
Some scientific papers claim that CBD has anti-inflammatory, analgesic and antipsychotic properties. In this regard, doctors hope that this substance will help pharmaceutical companies to develop effective drugs against many disorders and diseases combined with similar symptoms.
The list of such diseases includes, but isn’t limited by such pathological conditions:
To date, you will find no full-fledged drugs centered on CBD to combat these disorders, but many patients declare that the substance helps them to alleviate and even completely get rid of the symptoms.
Recently in the USA, where marijuana is still on the list of the very most dangerous psychoactive substances, there has been a real breakthrough in the field of pharmaceuticals – the Federal Food and Drug Administration (FDA) has approved the launch of the very first marijuana-based antiepileptic drug on the American market under Epidiolex name.
Its main component is precisely cannabidiol, the anticonvulsant effect of which the FDA has confirmed using its tests. Today, Epidiolex is employed to take care of severe kinds of epilepsy and such rare disorders that cause frequent and intense cramps in children, like Drave syndrome and Lenno-Gastaut syndrome.
And yet, before Epidiolex, there have been other drugs on the basis of the components of marijuana. For instance, the Belgian company Solvay Pharmaceuticals back in 1985 created Marinol (dronabinol), a medication that’s simply an artificial THC, which can be still used today to increase the appetite of cancer patients undergoing chemotherapy.
In 2010, British pharmaceutical group GW Pharmaceuticals developed Sativex, a drug containing equal areas of CBD and THC, to ease muscle cramps and other symptoms of multiple sclerosis.
The mechanism of action of cannabidiol
Although there’s still not really much data on how CBD includes a beneficial effect on your body, scientists still possess some ideas with this subject. Surprisingly, cannabidiol does not bind to the active sites of the cannabinoid receptors CB1 and CB2, as does the same THC. However it interacts with the GPR55 protein secreted in mental performance and peripheral organs. Researchers believe that this determines its antispasmodic effect.
In mental performance, CBD regulates the synaptic transmission process, during which signaling molecules are transmitted from neuron to another. The connections between these brain cells grow stronger when GPR55 is activated.
Convulsions occur when neurons become too active in signaling, flashing more regularly than necessary. Cannabidiol blocks the GPR55 protein, thus preventing overload of the synaptic transmission system, according to Ben Wally, head of research at GW Pharmaceuticals.
The partnership of this protein with CBD is confirmed by experiments with genetically modified rodents where epileptic seizures were caused. Those animals where GPR55 was present taken care of immediately cannabidiol treatment, and rats without protein continued to see convulsions.
Wally also believes that CBD can donate to the desensitization of the TRPV1 protein, which can be mixed up in transport of ions and calcium in the torso, which also helps relieve cramping. First, cannabidiol activates this protein, but quickly decreases the sensitivity of the ion channel, effectively blocking the transport of calcium into cells. By analogy with GPR55, animals that lack TRPV1 don’t respond to CBD.
Finally, this substance interacts with the channel of transport of adenosine, an anticonvulsant substance produced by the body. Wally believes that cannabidiol suppresses seizures, mainly due to its effect on adenosine, but more experiments are needed to ensure this hypothesis.
Such a wide variety of areas where CBD is active allows scientists to suggest that this substance may be useful in treating motor disorders, such as for instance Parkinson’s disease. And the interaction with serotonin receptors implies that cannabidiol may be used to take care of depression, anxiety and psychotic stages of bipolar disorder and schizophrenia.
Nevertheless, many researchers, such as for instance Roger Pertwee, a professor at the University of Aberdeen and the pinnacle of the pharmacology department of GW Pharmaceuticals, insist that without clinical data it can’t be confidently stated that the interaction of CBD with your receptors and proteins means so it causes a therapeutic effect of this substance.
High CBD Marijuana Varieties
Finally, we provides you with a listing of popular cannabidiol-dominated varieties so do you know what to ask about next amount of time in your telegram supermarket: